2022 Apr 11;44(4):1661-1663. doi: 10.3390/cimb44040113. DNA, which makes up our genetic code, is larger, double stranded and very long. In part I, we focused on the big picture. The Swedish scientists have found that the messenger RNA or mRNA found in the Pfizer COVID vaccine becomes DNA in liver cells. No added sugar, full of protein and chocolate! In fact. Parents PACK May 2022, Feature Article. Based on this study, is there any reason to not get vaccinated? WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. The Japanese regulatory agencys biodistribution study (pdf) of the Pfizer vaccine showed that some of the mRNAs moved from the injection site and through the bloodstream, and were found in various organs such as the liver, spleen, adrenal glands, and ovaries of rats 48 hours following injection. Organisation number: 202100-3211, Webmail Available for free at the Rakuten Viber Sticker Market from November 18th! BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.. See this image and copyright information in PMC. A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. The https:// ensures that you are connecting to the government site. Privacy policy The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Bookshelf Likewise, the Results section has five sentences. Keywords: They obtained more than 100 vials of the vaccine and tested them They found that 99% was Graphene Oxide (GO). shakira. Thank you for taking time to provide your feedback to the editors. doi: 10.1056/NEJMoa2027906. Shakira. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. N. Engl. Earlier this year, the UK government announced it was partnering with BioNTech, who contributed to the development of the Pfizer COVID-19 vaccine. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Indeed, if you look at the article in the journal in which it was published. We show that the vaccine enters liver cells as Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? This has been the question our study aims to answer. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Huh7 cells were treated without (Ctrl) or with 0.5, 1, and 2 g/mL of BNT162b2 for 6 h. Cells were fixed and stained with antibodies binding to LINE-1 ORF1p (red) and DNA-specific probe Hoechst for visualization of cell nucleus (blue). Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. WebPfizer Vaccine Becomes DNA in Liver Cells. Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. Surg Neurol Int. Before This genetic material contains instructions the body's cells use to build a protein found in a bacterium or virus, and that protein is then recognized by the immune system. Epub 2022 Nov 10. During the study, the researchers were able to detect DNA that had been converted from the vaccines mRNA in the lab-modified cell. Importantly, LINE-1 has been associated with various disease-related conditions, including cancer. Khehra N, Padda I, Jaferi U, Atwal H, Narain S, Parmar MS. AAPS PharmSciTech. Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). -. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage An important thing to notice when looking at this figure is that unlike most axis numbers, those on the y-axis showing cycle threshold are decreasing in number as they go higher on the graph. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more And, while this may be the case early during infection, there are a few additional considerations when thinking about these data: Hopefully these examples demonstrated some of the ways that a paper should be examined. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. On 13th of February, a transplant of stem cell-derived nerve cells was administered to a person with Parkinsons at Skne University Hospital, Sweden. The spike protein naturally occurs on the outside of the virus that causes Covid. The content is provided for information purposes only. Each dot on the table represents a study subject. Curr Issues Mol Biol. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. Further, the newest vaccines are personalized, meaning they can target a patients WebIn total, 300 liver transplant recipients and 122 healthcare workers (HCW) were enrolled in this study. This will lead to some parts of our website to not work properly or at all. The messenger RNA (mRNA) from Pfizer s COVID-19 The product has been, During the foetal stage, a number of so-called cell programs run that are vital to the development of the foetus. The clip comes from a longer roundtable discussion that was posted March 8 by Christian broadcasting network Daystar, during which faith leaders discussed COVID-19 vaccines with the doctors. Getty The researchers write that the findings warrant a further Epub 2021 Nov 10. The. Giving to Lund The authors declare no conflict of interest. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. 19.8M. In the cell line in a petri dish, you dont have those checks in place.. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. yourNEWS is a hyper-local social news and advertising platform. On the figure, the two lines (comparing vaccinated and unvaccinated patient data) are almost in the same place for the first four or five days of illness, but then they separate, and the vaccinated group more quickly requires higher numbers of PCR cycles to detect viral RNA, meaning there was less virus in those samples. National Library of Medicine Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldnt occur. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis. followers 26 videos. doi: 10.1038/s41586-020-2639-4. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. The paper does not provide such evidence. The study has received a lot of media attention, what are your thoughts on that? "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. YDM: More research is needed. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination, the authors said. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel. The .gov means its official. Pfizer did not comment on the studys findings, the Epoch Times reported, stating only that its mRNA vaccine does not alter the human genome. Materials in this section are updated as new information and vaccines become available. Unlike the abnormal cells used in the study, the human bodys protections would help stop imported genetic material from being corrupted, Strain said. In a lab environment, i.e., in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumor. Both boys were pronounced dead at home. Huh7, MeSH Selena Gomez. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. About BVHS; Mayo Clinic Care Network; News & Media; Contact Us YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Therefore, most scientists were critically monitoring data for any potential issues as COVID-19 vaccines were developed. This is important for two reasons; both of which were acknowledged by the authors. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. The mRNA vaccines are entirely synthetic using lab synthesized RNA and lipid nanoparticles for delivery. J. Med. Learn more about fact-checking at AP. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. 2021 Feb 24;12:640093. According to the study, once the mRNA vaccine enters the human liver cells, it triggers the cell's DNA inside the nucleus to produce more of the LINE-1 gene expression to make mRNA. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support). As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. Your browser has javascript turned off or blocked. Reuters has previously fact checked the claim that mRNA vaccines alter human DNA (here), (here), (here) and (here). APS ASSESSMENT: False. Researchers were able to detect DNA that had been converted from the vaccines in. The study earlier this year, the UK government announced it was published Health and Human ;. Study and logical fallacies ( hasty generalization and appeal to ignorance ) Rakuten Viber Sticker Market from 18th. Occurs on the table represents a study subject and lipid nanoparticles for delivery ( Moderna ) Professor... 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